A comparative pharmacokinetic study of berberine and palmatine after oral administration of Rhizoma Coptidis extract (96mg/kg,\ncontaining berberine 22mg/kg and palmatine 5mg/kg based on body weight) was performed in normal and postinflammation\nirritable bowel syndrome (PI-IBS) rats, induced by in tracolonic instillation of acetic acid and restraint stress. Quantification\nof berberine and palmatine in rat plasma was achieved by using a sensitive and rapid UPLC-MS/MS method. Plasma samples\nwere collected at 13 different time points and the pharmacokinetic parameters were analyzed by WinNonlin software. The\nsignificant differences in the pharmacokinetic behaviors, such as ????max, AUC(0ââ?¬â??????), ????????/????, and CL/????, of berberine and palmatine\nwere found between normal and PI-IBS model rats. The results indicated that PI-IBS pathological conditions in rats could alter the\npharmacokinetic behavior of drug. Preclinical pharmacokinetic studies are usually carried out on healthy animals. However, we\nshould pay more attention to the fact that the change of pharmacokinetic behavior plays an important role on efficacy. It is essential\nto investigate the pharmacokinetics of the drug in disease status.
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